Efficient side-chain deacylation of polymyxin B1 in recombinant Streptomyces strains.

Xiaojing WangKai WuHanzhi ZhangJing LiuZhijun YangJing BaiHao LiuLei Shao

Published in: Biotechnology letters (2022)

These results show that SAL701 is effective in increasing the cyclic heptapeptide moiety of polymyxin B1. These properties of the biocatalyst may enable its development in the industrial production of polymyxins antibiotics.

Keyphrases

gram negative
escherichia coli
heavy metals
wastewater treatment
cell free