LncRNA MDRL Mitigates Atherosclerosis through miR-361/SQSTM1/NLRP3 Signaling.

Ling YouYanjie ZhengJing YangQian HouLianxia WangYan ZhangChunxia Zhao Ruiqin Xie

Published in: Mediators of inflammation (2022)

In summary, MDRL alleviates NLRP3 inflammasome activation and apoptosis in VSMCs through miR-361/SQSTM1/NLRP3 pathway during atherogenesis. These data indicate that MDRL and inhibition of miR-361 represent potential therapeutic targets in atherosclerosis-related diseases.

Keyphrases

nlrp inflammasome
long non coding rna
cell proliferation
long noncoding rna
cardiovascular disease
oxidative stress
electronic health record
cell death
risk assessment
radiation therapy
machine learning
radiation induced
artificial intelligence
human health