Combined quantitation of HMGA2 mRNA, microRNAs, and mitochondrial-DNA content enables the identification and typing of thyroid tumors in fine-needle aspiration smears.
Sergei Evgenievich TitovMikhail K IvanovPavel S DemenkovGevork A KatanyanEugenia S KozorezovaAnastasia V MalekYulia A VeryaskinaIgor F ZhimulevPublished in: BMC cancer (2019)
The study shows the feasibility of the preoperative differential diagnosis of thyroid nodules using a panel of several molecular markers by a simple PCR-based method. Combining markers of different types increases the accuracy of classification.
Keyphrases
- mitochondrial dna
- fine needle aspiration
- copy number
- ultrasound guided
- machine learning
- ms ms
- mass spectrometry
- deep learning
- patients undergoing
- liquid chromatography tandem mass spectrometry
- gene expression
- high performance liquid chromatography
- tandem mass spectrometry
- genome wide
- single molecule
- high resolution
- bioinformatics analysis