SNP-PCR genotyping links alterations in the GABAA receptor (GABRG3: rs208129) and RELN (rs73670) genes to autism spectrum disorder among peadiatric Iraqi Arabs.

Zainab A Ali Akeel Abed Yasseen Katherine Ann McAllister Arafat Al-DujailliAhmed J Al-KaraqullyAlaa Salah Jumaah

Published in: Molecular biology reports (2022)

GABRG3 SNP rs208129 is a leading biomarker to predict genetic vulnerability to ASD in Iraqi Arabs. Expanded SNP panels and increased sample sizes are required for future GABRG3 studies, and to reach a consensus on RELN utility. Future ASD screening programs in Iraq should include genetic metrics in addition to clinical phenotype assessments.

Keyphrases

genome wide
autism spectrum disorder
dna methylation
attention deficit hyperactivity disorder
intellectual disability
copy number
current status
climate change
public health
gene expression
genetic diversity
high throughput
single cell