Tetrahydrobiopterin synthesis and metabolism is impaired in dystrophin-deficient mdx mice and humans.

Angus LindsayBailey KempAlexie A LarsonCory W BaumannPreston M McCourtJohn HolmPeter KarachunskiDawn A LoweJames M Ervasti

Published in: Acta physiologica (Oxford, England) (2021)

These data demonstrate that impaired tetrahydrobiopterin synthesis is associated with dystrophin loss and treatment with tetrahydrobiopterin improves striated muscle histopathology and skeletal muscle function in mdx mice.

Keyphrases

duchenne muscular dystrophy
skeletal muscle
high fat diet induced
insulin resistance
muscular dystrophy
wild type
type diabetes
big data
adipose tissue
machine learning