The Role of Deubiquitinating Enzyme in Head and Neck Squamous Cell Carcinoma.
Shengjian JinYasusei KudoTaigo HoriguchiPublished in: International journal of molecular sciences (2022)
Ubiquitination and deubiquitination are two popular ways for the post-translational modification of proteins. These two modifications affect intracellular localization, stability, and function of target proteins. The process of deubiquitination is involved in histone modification, cell cycle regulation, cell differentiation, apoptosis, endocytosis, autophagy, and DNA repair after damage. Moreover, it is involved in the processes of carcinogenesis and cancer development. In this review, we discuss these issues in understanding deubiquitinating enzyme (DUB) function in head and neck squamous cell carcinoma (HNSCC), and their potential therapeutic strategies for HNSCC patients are also discussed.
Keyphrases
- reactive oxygen species
- cell cycle
- dna repair
- oxidative stress
- end stage renal disease
- dna damage
- endoplasmic reticulum stress
- cell death
- cell proliferation
- ejection fraction
- chronic kidney disease
- newly diagnosed
- papillary thyroid
- prognostic factors
- dna methylation
- peritoneal dialysis
- dna damage response
- gene expression
- patient reported outcomes
- squamous cell carcinoma
- cell cycle arrest
- squamous cell