Predicting QRS and PR interval prolongations in humans using nonclinical data.

Linnéa BergenholmJ ParkinsonJ MettetalN D EvansM J ChappellT Collins

Published in: British journal of pharmacology (2017)

Small changes in vitro and in vivo consistently translated to meaningful PR/QRS changes in humans across compounds. Assuming broad applicability of these approaches to assess cardiovascular safety risk for non-arrhythmic drugs, this study provides a means of predicting human QRS/PR effects of new drugs from effects observed in nonclinical studies.

Keyphrases

cardiac resynchronization therapy
endothelial cells
heart failure
electronic health record
left ventricular
induced pluripotent stem cells
big data
artificial intelligence
deep learning