Only Hyperuricemia with Crystalluria, but not Asymptomatic Hyperuricemia, Drives Progression of Chronic Kidney Disease.

Markus SellmayrMoritz Roman Hernandez PetzscheQiuyue MaNils KrügerHelen LiapisAndreas BrinkBarbara LenzMaria Lucia AngelottiViviane GnemmiChristoph KuppeHyojin KimEric Moniqué Johannes BindelsFerenc TajtiJulio Saez-RodriguezMaciej LechRafael Kramann Paola Romagnani Hans-Johachim Anders Stefanie Steiger

Published in: Journal of the American Society of Nephrology : JASN (2020)

Asymptomatic hyperuricemia does not affect CKD progression unless UA crystallizes in the kidney. UA crystal granulomas develop late in chronic UA crystal nephropathy and contribute to CKD progression because UA crystals trigger M1-like macrophage-related interstitial inflammation and fibrosis. Targeting proinflammatory macrophages, but not JAK/STAT signaling, can attenuate granulomatous interstitial nephritis.

Keyphrases

chronic kidney disease
end stage renal disease
uric acid
oxidative stress
adipose tissue
metabolic syndrome
systemic sclerosis
interstitial lung disease
peritoneal dialysis
ionic liquid
liver fibrosis