Increased circulating levels of angiotensin-(1-7) in severely ill COVID-19 patients.
Ana Luiza Valle MartinsFilipe Alex da SilvaLucas Bolais-RamosGisele Capanema de OliveiraRenata Cunha RibeiroDanilo Augusto Alves PereiraFilippo AnnoniMirella Monique Lana DinizThuanny Granato Fonseca SilvaBruna ZivianniAlexandre Carvalho CardosoJuliana Carvalho MartinsDaisy Motta-SantosMaria José Campagnole-SantosFabio Silvio TacconeThiago Verano-BragaRobson Augusto Souza Dos SantosPublished in: ERJ open research (2021)
This letter reports an unexpected increase of the ACE2 product angiotensin-(1-7) and a parallel decrease of its substrate angiotensin II, suggesting a dysregulation of the renin-angiotensin system towards angiotensin-(1-7) formation in #COVID19 patients https://bit.ly/3xFXuTU.