Impact of Gas Flow and Humidity on Trans-Nasal Aerosol Deposition via Nasal Cannula in Adults: A Randomized Cross-Over Study.

Luciana AlcoforadoArzu AriJacqueline de Melo BarcelarSimone Cristina S BrandãoJames B FinkArmele Dornelas de Andrade

Published in: Pharmaceutics (2019)

Both flow and active heated humidity inversely impact aerosol delivery through HFNC. Nevertheless, aerosol administration across the range of commonly used flows can provide measurable levels of lung deposition in healthy adult subjects (NCT02519465).

Keyphrases

water soluble
extracorporeal membrane oxygenation
intensive care unit
young adults
acute respiratory distress syndrome
mechanical ventilation