Procalcitonin as a biomarker for predicting bacterial infection in chimeric antigen receptor T-cell therapy recipients.
Marissa Z PowellKristin C ColeRadhika BansalMatthew A HathcockArushi KhuranaN Nora BennaniYucai WangJonas PaludoJose C Villasboas BisnetoStephen M AnsellPatrick B JohnstonYi LinJason N BarretoPublished in: Cancer medicine (2023)
Elevated serum PCT concentrations above 0.4 ng/mL at time of first fever after CAR-T infusion was significantly associated with confirmed bacterial infection. Furthermore, rigorous, prospective studies should validate our findings and evaluate serial PCT measurements to optimize antimicrobial use after CAR-T therapy.