Tumor Necrosis Factor Induces Obliterative Pulmonary Vascular Disease in a Novel Model of Connective Tissue Disease-Associated Pulmonary Arterial Hypertension.
Richard D BellR James WhiteMaria L Garcia-HernandezEmily WuHomaira RahimiRoberta G MarangoniPamelia SlatteryStacey DuemmelMarc NuzzoNelson HuertasMin YeeMichael A O'ReillyCraig MorrellChristopher T RitchlinEdward M SchwarzBenjamin D KormanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
The TNF-Tg mouse represents a novel model of CTD-PAH, recapitulates key disease features, and can serve as a valuable tool for discovery and assessment of therapeutics.