Joint analysis of mutational and transcriptional landscapes in human cancer reveals key perturbations during cancer evolution.
Jae-Won ChoJingyi CaoMartin HembergPublished in: Genome biology (2024)
Our results show that lung cancer and chronic myeloid leukemia maintain a high clonal and transcriptional diversity, and we find little evidence in favor of clonal sweeps. This suggests that for these cancers selection based solely on growth rate is unlikely to be the dominating driving force during cancer evolution.