Premature senescence of the liver in Alagille patients.

Giulia JannoneCatherine de MagnéeRoberto TambucciJonathan EvraertsJoachim RavauMustapha NajimiEtienne Marc Sokal

Published in: PloS one (2023)

We demonstrate for the first time that ALGS livers display important premature senescence despite Jagged1 mutation, underlying the complexity of senescence and SASP development pathways.

Keyphrases

dna damage
endothelial cells
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported
oxidative stress