Excess Mucin Impairs Subglottic Epithelial Host Defense in Mechanically Ventilated Patients.

Jason PowellJames P GarnettMichael W MatherFaye A H CoolesAndrew NelsonBernard VerdonJon ScottKasim JiwaMarie-Hélène Ruchaud-SparaganoStephen P CummingsJohn D PerryStephen E WrightJanet A WilsonJeffrey PearsonChris WardA John Simpson

Published in: American journal of respiratory and critical care medicine (2019)

Mechanical ventilation in the ICU is characterized by substantial mucin secretion and neutrophilic inflammation. Mucin impairs neutrophil function and promotes bacterial growth. Mucolytic agents reverse mucin-mediated neutrophil dysfunction. Enhanced mucus disruption and removal has potential to augment preventive benefits of subglottic drainage.

Keyphrases

mechanical ventilation
intensive care unit
acute respiratory distress syndrome
end stage renal disease
oxidative stress
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
extracorporeal membrane oxygenation
ultrasound guided
climate change
patient reported