Network pharmacology and molecular docking integrated strategy to investigate the pharmacological mechanism of palmatine in Alzheimer's disease.

Hongyan PeiJianning ZengWeijia ChenZhongmei HeRui Du

Published in: Journal of biochemical and molecular toxicology (2022)

Palmatine has neuroprotective effects. Palmatine could effectively ameliorate memory impairment in AD mice by promoting the PI3K-AKT pathway. Molecular docking results showed that palmatine has a better binding ability with mTOR.

Keyphrases

molecular docking
molecular dynamics simulations
cell proliferation
working memory
high fat diet induced
type diabetes
metabolic syndrome
dna binding
adipose tissue