Two new α -pyrone-containing polyketides isolated from the fungus Aspergillus aureoterreus .

Two undescribed α -pyrone-containing polyketide derivatives designated aurovertins V ( 1 ) and W ( 2 ), and a known analogue ( 3 ), were isolated from the fungus Aspergillus aureoterreus . Their structures including the absolute configuration were elucidated on the basis of extensive spectroscopic methods and theoretical ECD calculation. Compound 1 is the first example of aurovertins with a 7 R configuration, whereas 2 comprises a S configuration for C-6 and a Z geometry of the double bond Δ 8 . Both 1 and 2 showed no cytotoxicity against human cancer cell lines HL-60, SU-DHL-2 and U266) at the concentration of 20.0 μM.