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Disruptive natural selection by male reproductive potential prevents underexpression of protein-coding genes on the human Y chromosome as a self-domestication syndrome.

Mikhail P PonomarenkoMaxim KleshchevPetr PonomarenkoIrina ChadaevaEkaterina SharypovaDmitry RasskazovSemyon KolmykovIrina DrachkovaGennady VasilievNatalia GutorovaElena IgnatievaLudmila SavinkovaAnton BogomolovLudmila OsadchukAlexandr OsadchukDmitry Oshchepkov
Published in: BMC genetics (2020)
Overall, our findings seem to support a self-domestication syndrome with disruptive natural selection by male reproductive potential preventing Y-linked underexpression of a protein.
Keyphrases
  • endothelial cells
  • case report
  • protein protein
  • human health
  • genome wide
  • binding protein
  • induced pluripotent stem cells
  • mouse model
  • gene expression
  • transcription factor