NELF coordinates Pol II transcription termination and DNA replication initiation.

Chihiro NakayamaYasukazu DaigakuYuki AoiQi FangHitoshi KurumizakaAli ShilatifardMichael Tellier Takayuki Nojima

Published in: bioRxiv : the preprint server for biology (2024)

transcript is up-regulated in colorectal tumors NELF-C protein is mandatory for the transition between G1-S phases during cell cycleNELF-C loss impairs transcription termination independently of Pol II promoter-proximal pausingNELF-C loss leads Pol II to invade DNA replication initiation zones.

Keyphrases

transcription factor
single cell
dna methylation
gene expression
rna seq
bone marrow