Advanced Glycation End Products Induce Atherosclerosis via RAGE/TLR4 Signaling Mediated-M1 Macrophage Polarization-Dependent Vascular Smooth Muscle Cell Phenotypic Conversion.

Yujie Xing Shuo Pan Ling ZhuQianwei CuiZhiguo Tang Zhongwei Liu Fuqiang Liu

Published in: Oxidative medicine and cellular longevity (2022)

AGEs induced activation of RAGE/TLR4/FOXC2 signaling, which featured macrophage with Dll4 high expression during M1 polarization. These macrophages promoted contractile-synthetic phenotypic conversion of VSMCs through the Dll4/Notch pathway after direct cell-to-cell contacts.

Keyphrases

smooth muscle
single cell
inflammatory response
cardiovascular disease
adipose tissue
type diabetes
cell proliferation
skeletal muscle
high glucose
nuclear factor
drug induced
stress induced