Add-On Therapy with DPP-4 Inhibitors May Improve Renal Function Decline in α-Glucosidase Inhibitor and Metformin Users: A Retrospective Observational Study.
Takeshi OsonoiMiyoko SaitoNaoya KodaSatako DouguchiTakako NakanoKensuke OfuchiMakoto KatohPublished in: Diabetes, metabolic syndrome and obesity : targets and therapy (2020)
In the present study, patients treated with DPP-4 inhibitors had a significantly slower annual loss of kidney function. The benefit appears pronounced in α-glucosidase inhibitor and metformin users with advanced renal dysfunction. These results suggest that the beneficial effects of DPP-4 inhibitors on kidney function may have occurred in the presence of an α-glucosidase inhibitor and/or metformin.