Risk Factors for Recurrence after Robot-Assisted Radical Hysterectomy for Early-Stage Cervical Cancer: A Multicenter Retrospective Study.
Jordi Ponce SebastiàSergi FernandezAntonio Gil-MorenoPluvio J CoronadoJesús De la RosaHenrique NabaisGinés HernándezAnna TaltavullJuan Gilabert-EstellésSergio Martínez-RománManel BarahonaMarc BarahonaMaría Ángeles Martínez-MaestrePublished in: Cancers (2020)
This retrospective analysis aimed to assess the risk factors for recurrence in patients diagnosed with early-stage cervical cancer (≤IB1 or IIA1, FIGO 2009) undergoing robot-assisted radical hysterectomy in Spain and Portugal between 2009 and 2018. A second primary objective was to audit the oncological outcomes according to quality indicators (QI) proposed by the European Society of Gynecology Oncology (ESGO). The study population included 239 women. After a median follow-up of 51 months, recurrence occurred in 26 patients (10.9%). Independent factors for recurrence were clinical tumor size > 20 mm (hazard ratio (HR) 2.37), adenocarcinoma as histological type (HR 2.51), positive pelvic lymph nodes (HR 4.83), tumor grade 2 (HR 4.99), tumor grade 3 (HR 8.06), and having not performed sentinel lymph node biopsy (SLNB) (HR 4.08). All 5 QI selected were surpassed by our results. In patients with early-stage cervical cancer undergoing robotic radical hysterectomy, clinicians should be aware that tumor grade 2 and 3, tumor size > 20 mm, adenocarcinoma, positive pelvic nodes, and lack of performance of SLNB are risk factors for recurrence. Fulfillment of QI targets of the ESGO might be considered as an objective oncological outcome indicator supporting the minimally invasive approach for early-stage cervical cancer treatment.
Keyphrases
- early stage
- robot assisted
- sentinel lymph node
- minimally invasive
- lymph node
- end stage renal disease
- ejection fraction
- rectal cancer
- newly diagnosed
- chronic kidney disease
- squamous cell carcinoma
- palliative care
- prognostic factors
- clinical trial
- locally advanced
- pregnant women
- peritoneal dialysis
- insulin resistance
- patient reported
- radical prostatectomy