Controlled Release of Vancomycin and Tigecycline from an Orthopaedic Implant Coating Prevents Staphylococcus aureus Infection in an Open Fracture Animal Model.
Alexandra I StavrakisS ZhuA H LoftinX WeixianJ NiskaV HegdeT SeguraNicholas M BernthalPublished in: BioMed research international (2019)
Vancomycin and tigecycline can be encapsulated in a polymer coating and released over time to maintain therapeutic levels during the perioperative period. Our results suggest that antibiotic coatings can be used to prevent implant infection and osteomyelitis in the setting of open fracture. This novel open fracture mouse model can be used as a powerful in vivo preclinical tool to evaluate and optimize the treatment of open fractures before further studies in humans.
Keyphrases
- minimally invasive
- mouse model
- staphylococcus aureus
- methicillin resistant staphylococcus aureus
- acinetobacter baumannii
- hip fracture
- soft tissue
- klebsiella pneumoniae
- patients undergoing
- cardiac surgery
- drug resistant
- acute kidney injury
- multidrug resistant
- stem cells
- cell therapy
- pseudomonas aeruginosa
- smoking cessation