COVID-19 severity gradient differentially dysregulates clinically relevant drug processing genes in nasopharyngeal swab samples.

Chukwunonso K NwabufoJessica LucAllison McGeerJeremy Alexander HirotaSamira MubarekaAndrew C DoxeyTheo J Moraes

Published in: British journal of clinical pharmacology (2024)

The severity of COVID-19 is associated with the dysregulation of DMETs involved in processing commonly prescribed drugs, suggesting potential disease-drug interactions, especially for narrow therapeutic index drugs.

Keyphrases

coronavirus disease
sars cov
genome wide
respiratory syndrome coronavirus
emergency department
gene expression
dna methylation
risk assessment
adverse drug
genome wide analysis