Bio-orthogonal "click-and-release" donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S).

Andrea K SteigerYang YangMaksim RoyzenMichael D Pluth

Published in: Chemical communications (Cambridge, England) (2018)

Hydrogen sulfide (H2S) is an important biomolecule with high therapeutic potential. Here we leverage the inverse-electron demand Diels-Alder (IEDDA) click reaction between a thiocarbamate-functionalized trans-cyclooctene and a tetrazine to deliver carbonyl sulfide (COS), which is quickly converted to H2S by the uniquitous enzyme carbonic anhydrase (CA), thus providing a new strategy for bio-orthogonal COS/H2S donation.

Keyphrases

quantum dots
electron transfer
mass spectrometry
protein kinase
solar cells
simultaneous determination
electron microscopy