α-Synuclein Seed Amplification in CSF and Brain from Patients with Different Brain Distributions of Pathological α-Synuclein in the Context of Co-Pathology and Non-LBD Diagnoses.
Moriah R ArnoldDavid G CoughlinBarbara H BrumbachDenis S SmirnovLuis Concha-MarambioCarly M FarrisYihua MaYongya KimEdward N WilsonJeffrey A KayeAnnie HinikerRandy L WoltjerDouglas R GalaskoJoseph F QuinnPublished in: Annals of neurology (2022)
CSF αSyn-SAA reliably identifies αSyn seeds in patients with diffuse αSyn pathology in the context of co-pathology and non-Lewy body disease (LBD) diagnoses. The analysis of brain homogenates suggests that pathological αSyn in the amygdala might differ from pathological αSyn in the frontal cortex. The αSyn-SAA might facilitate the differential diagnosis of dementias with mixed pathologies. ANN NEUROL 2022;92:650-662.