Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis.
Giuseppe MocciKatyayani SukhavasiTiit ÖrdSean BankierProsanta SinghaUma Thanigai ArasuOlayinka Oluwasegun AgbabiajePetri MäkinenLijiang MaChani J HodonskyRédouane AherrahrouLars MuhlJianping LiuSonja GustafssonByambajav ByandelgerYing WangSimon KoplevUrban LendahlGary K OwensNicholas J LeeperGerard PasterkampMichael VanlandewijckTom MichoelArno RuusaleppKe HaoSuo Ctc Bladder CommitteeMarika VäliHeli JärveMichal MokryMete CivelekClint T MillerJason C KovacicMinna U KaikkonenChrister BetsholtzJohan L M BjörkegrenPublished in: Circulation research (2024)
By identifying and integrating the most gene-rich single-cell subclusters of atherosclerosis to date with a coronary artery disease framework of GRNs, GRN39 was identified and independently validated as being critical for the transformation of contractile SMCs into an osteogenic phenotype promoting advanced, symptomatic atherosclerosis.