Progress towards the syntheses of Bactobolin A and C4- epi -Bactobolin A using a sulfamate-tethered aza -Wacker cyclization strategy.

We present a progress report towards Bactobolin A and C4- epi -Bactobolin A. Sulfamate-tethered aza -Wacker cyclization followed by a Tsuji-Wacker ketone synthesis furnishes a key tricyclic intermediate which we hypothesize can be elaborated into C4- epi -Bactobolin A. Epimerization of one of the stereocenters of this compound furnishes an intermediate which we hypothesize can be elaborated into Bactobolin A.