Cnot3 is required for male germ cell development and spermatogonial stem cell maintenance.

Qing ChenSafia Malki Xiaojiang XuBrian BennettBrad L LackfordOleksandr KirsanovChristopher B GeyerGuang Hu

Published in: bioRxiv : the preprint server for biology (2023)

leads to total germ cell loss and male infertility. CNOT3 represses transcripts encoding factors involved in spermatogonial differentiation.CNOT3 protects spermatogonial stem cells maintenance via GSH/redox pathway.

Keyphrases

germ cell
stem cells
cell therapy
fluorescent probe
polycystic ovary syndrome
type diabetes
insulin resistance
metabolic syndrome