Variability of polygenic prediction for body mass index in Africa.
Tinashe ChikoworeKristi LällLisa K MicklesfieldZane LombardJulia H GoedeckeSegun FatumoShane A NorrisReedik MagiMichele RamsayPaul W FranksGuillaume PareAndrew P MorrisPublished in: Genome medicine (2024)
Our findings highlight the role of gene-environment interactions in PRS prediction variability in Africa. PRS methods that correct for these interactions, coupled with the increased representation of Africans in GWAS, may improve PRS prediction in Africa.