PES1 promotes BET inhibitors resistance and cells proliferation through increasing c-Myc expression in pancreatic cancer.

Xin JinRui FangPing FanLipeng ZengBin ZhangXiaoming LuTao Liu

Published in: Journal of experimental & clinical cancer research : CR (2019)

We have shown that PES1 could be one of the promoting factors of tumor growth and a prognosis-related protein of pancreatic cancer. Targeting PES1 with CDK5 inhibitors might help overcome cancer cell resistance to BET inhibitors in pancreatic cancer cells.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
cell cycle
cancer therapy
cell proliferation
binding protein