Androgen Receptor Gene Pathway Upregulation and Radiation Resistance in Oligometastatic Prostate Cancer.
Helen SaxbyStergios BoussiosChristos MikropoulosPublished in: International journal of molecular sciences (2022)
Stereotactic ablative body radiotherapy (SABR) is currently used as a salvage intervention for men with oligometastatic prostate cancer (PC), and increasingly so since the results of the Stereotactic Ablative Body Radiotherapy for the Comprehensive Treatment of Oligometastatic Cancers (SABR-COMET) trial reported a significant improvement in overall survival with SABR. The addition of androgen deprivation therapy (ADT) to localised prostate radiotherapy improves survival as it sensitises PC to radiotherapy-induced cell death. The importance of the androgen receptor (AR) gene pathway in the development of resistance to radiotherapy is well established. In this review paper, we will examine the data to determine how we can overcome the upregulation of the AR pathway and suggest a strategy for improving outcomes in men with oligometastatic hormone-sensitive PC.
Keyphrases
- prostate cancer
- early stage
- locally advanced
- radiation induced
- radiation therapy
- cell death
- radical prostatectomy
- copy number
- clinical trial
- signaling pathway
- cell proliferation
- type diabetes
- small cell lung cancer
- high glucose
- middle aged
- brain metastases
- free survival
- genome wide identification
- transcription factor
- big data
- weight loss
- smoking cessation
- machine learning