Red blood cell indices and anaemia as causative factors for cognitive function deficits and for Alzheimer's disease.

Laura M WinchesterJohn PowellSimon LovestoneAlejo J Nevado-Holgado

Published in: Genome medicine (2018)

Lower haemoglobin levels in blood are associated to poor cognitive function and AD. We have used UK Biobank SNP data to determine the relationship between cognitive testing and haemoglobin measures and suggest that haemoglobin level and therefore anaemia does have a primary causal impact on cognitive performance.

Keyphrases

red blood cell
iron deficiency
traumatic brain injury
genome wide
electronic health record
cognitive decline
big data
gene expression
dna methylation
machine learning
deep learning