Antihypertensive Drugs for the Prevention of Atrial Fibrillation: A Drug Target Mendelian Randomization Study.
Sven GeurtsMartijn J TillyZuolin LuBruno H C StrickerJaap W DeckersNatasja M S De GrootClint T MillerMohammad Arfan IkramMaryam KavousiPublished in: Hypertension (Dallas, Tex. : 1979) (2024)
Our results indicated that lowering systolic blood pressure via protein targets of various antihypertensive drugs seems promising for AF prevention. Our findings inform future clinical trials and have implications for repurposing antihypertensive drugs for AF prevention.
Keyphrases
- blood pressure
- atrial fibrillation
- hypertensive patients
- clinical trial
- heart rate
- heart failure
- catheter ablation
- left atrial
- drug induced
- oral anticoagulants
- left atrial appendage
- type diabetes
- metabolic syndrome
- coronary artery disease
- percutaneous coronary intervention
- blood glucose
- emergency department
- skeletal muscle
- current status
- adipose tissue
- open label
- insulin resistance
- phase iii