Login / Signup

Bipolar Tumor-Associated Macrophages in Ovarian Cancer as Targets for Therapy.

Vijayalaxmi GuptaFiona E YullDineo Khabele
Published in: Cancers (2018)
Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • bipolar disorder
  • stem cells
  • young adults
  • risk assessment
  • cell proliferation
  • cell free
  • squamous cell
  • cell therapy
  • smoking cessation
  • chemotherapy induced