Effective Extracorporeal Photopheresis of Patients with Transplantation Induced Acute Intestinal GvHD and Bronchiolitis Obliterans Syndrome.
Robin ReschkeStephanie ZimmerlichChristine DöhringGerhard BehreMirjana ZiemerPublished in: Biomedicines (2022)
Background : Patients with steroid-refractory intestinal acute graft-versus-host disease (aGvHD) and bronchiolitis obliterans syndrome (BOS) represent a population with a high need for alternative and effective treatment options. Methods : We report real-life data from 18 patients treated with extracorporeal photopheresis (ECP). This cohort consisted of nine patients with steroid-refractory intestinal aGvHD and nine patients with BOS. Results : We document partial or complete clinical response and reduction of symptoms in half of the patients with intestinal acute GvHD and patients with BOS treated ECP. Responding patients tended to stay on treatment longer. In patients with BOS, stabilization of lung function and forced expiratory volume was observed, whereas, less abdominal pain, less diarrhea, and a reduction of systemic corticosteroids were seen in patients with intestinal acute GvHD. Conclusions : ECP might not only abrogate symptoms but also reduce mortality caused by complications from high-dose steroid treatment. Taken together, ECP offers a serious treatment avenue for patients with steroid-refractory intestinal acute GvHD and BOS.
Keyphrases
- liver failure
- lung function
- respiratory failure
- high dose
- drug induced
- end stage renal disease
- newly diagnosed
- allogeneic hematopoietic stem cell transplantation
- chronic kidney disease
- abdominal pain
- chronic obstructive pulmonary disease
- type diabetes
- low dose
- stem cells
- risk factors
- cardiovascular disease
- hepatitis b virus
- electronic health record
- mesenchymal stem cells
- bone marrow
- case report
- acute lymphoblastic leukemia
- sleep quality
- acute myeloid leukemia
- extracorporeal membrane oxygenation
- artificial intelligence
- peritoneal dialysis
- cell therapy
- stem cell transplantation
- data analysis