MRE11:p.K464R mutation mediates olaparib resistance by enhancing DNA damage repair in HGSOC.
Xucui ZhuangRourou XiaoYu FuBin YangJunpeng FanFunian LuTianyu QinXiaohang YangXingyuan HuJingjing YinWenting LiXiaoyan KangGang ChenDianxing HuChaoyang SunPublished in: Cell & bioscience (2023)
Our findings provide a theoretical basis for MRE11:p.K464R mutation as a specific indicator of resistance monitoring in Olaparib treatment, and the exploration of its resistance mechanism provides a novel insights for the formulation of combination ther therapies after Olaparib resistance.