The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells.

Hitoshi NiwaAkira NakamuraMakoto UrataMaki Shirae-KurabayashiShigehiro KurakuSteven RussellSatoshi Ohtsuka

Published in: BMC evolutionary biology (2016)

These data indicate that the function of mouse Sox2 supporting pluripotency is based on an evolutionally conserved activity of the Group B1 Sox family. Since pluripotent stem cell population in developmental process could be regarded as the evolutional novelty in vertebrates, it could be regarded as a co-optional use of their evolutionally conserved function.

Keyphrases

transcription factor
stem cells
induced apoptosis
oxidative stress
electronic health record
machine learning
cell death
signaling pathway
artificial intelligence
deep learning