Single-Cell Dissection of the Immune Response After Acute Myocardial Infarction.
Irene V van BloklandRoy OelenHilde E GrootJan-Walter BenjaminsKami PekayvazCorinna LosertViktoria KnottenbergMatthias HeinigLeo NicolaiKonstantin StarkPim van der HarstLude H FrankeMonique G P van der WijstPublished in: Circulation. Genomic and precision medicine (2024)
Our analyses revealed the immunologic pathways disturbed by STEMI, specifying affected cell types and disease stages. Additionally, we provide insights into patients expected to benefit most from anti-inflammatory treatments by identifying the genetic variants and disease stage at which these variants affect the outcome of these (drug-targeted) pathways. These findings advance our knowledge of the immune response post-STEMI and provide guidance for future therapeutic studies.
Keyphrases
- single cell
- immune response
- acute myocardial infarction
- percutaneous coronary intervention
- rna seq
- end stage renal disease
- anti inflammatory
- ejection fraction
- st elevation myocardial infarction
- st segment elevation myocardial infarction
- newly diagnosed
- healthcare
- dendritic cells
- high throughput
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- copy number
- cell therapy
- toll like receptor
- heart failure
- acute coronary syndrome
- left ventricular
- mesenchymal stem cells
- patient reported outcomes
- bone marrow