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Canonical Wnt transcriptional complexes are essential for induction of nephrogenesis but not maintenance or proliferation of nephron progenitors.

Helena BugacovBalint DerSunghyun KimNils O LindströmAndrew P McMahon
Published in: bioRxiv : the preprint server for biology (2023)
The study provides a mechanistic understanding of Wnt/ β-catenin activity in self-renewal and differentiation of mammalian nephron progenitors.
Keyphrases
  • cell proliferation
  • stem cells
  • signaling pathway
  • gene expression
  • epithelial mesenchymal transition
  • transcription factor
  • heat stress