Automating iPSC generation to enable autologous photoreceptor cell replacement therapy.

Laura R BohrerNicholas E StoneNathaniel K MullinAndrew P VoigtKristin R AnfinsonJessica L FickViviane LuangphakdyBradley HittleKimerly PowellGeorge F MuschlerRobert F MullinsEdwin M StoneBudd A Tucker

Published in: Journal of translational medicine (2023)

We have successfully developed a robotic iPSC generation platform and standard operating procedures for production of high-quality photoreceptor precursor cells that are compatible with current good manufacturing practices. This system will enable clinical grade production of iPSCs for autologous retinal cell replacement.

Keyphrases

cell therapy
replacement therapy
single cell
bone marrow
induced apoptosis
healthcare
primary care
induced pluripotent stem cells
optical coherence tomography
stem cells
diabetic retinopathy
smoking cessation
minimally invasive
cell cycle arrest
cell death
cell proliferation
oxidative stress