Associations between structural brain changes and blood neurofilament light chain protein in treatment-resistant schizophrenia.
Brandon-Joe CiliaDhamidhu EratneCassandra M J WannanCharles B MalpasShorena JanelidzeOskar HanssonIan EverallChad A BousmanNaveen ThomasAlexander F SantilloDennis VelakoulisChristos PantelisPublished in: medRxiv : the preprint server for health sciences (2024)
The association between regional thickness reduction of the insula bilaterally and plasma NfL may reflect a neurodegenerative process during the course of TRS. The findings of the present study suggest that some level of cortical degeneration localised to the bilateral insula may exist in people with TRS, which is not observed in the normal population.