14-3-3 [Formula: see text]-reported early synaptic injury in Alzheimer's disease is independently mediated by sTREM2.
Marcel Seungsu WooJohanna NilssonJoseph TherriaultNesrine RahmouniAnn BrinkmalmAndrea L BenedetNicholas J AshtonArthur C MacedoStijn ServaesYi-Ting WangCécile TissotJaime Fernandez AriasSeyyed Ali HosseiniMira ChamounFiroza Z LussierThomas K KarikariJenna StevensonChristina MayerJoão Pedro Ferrari-SouzaEliane KobayashiGassan MassarwehNicolaus KrögerTharick A PascoalSerge GauthierHenrik ZetterbergKaj BlennowPedro Rosa-NetoPublished in: Journal of neuroinflammation (2023)
Our results advertise that sTREM2 is mediating synaptic injury at the early stages of tau accumulation, underlining the importance of microglia activation for AD disease propagation.