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Peptide-Coated Platinum Nanoparticles with Selective Toxicity against Liver Cancer Cells.

Michal S ShoshanThomas VonderachBodo HattendorfHelma Wennemers
Published in: Angewandte Chemie (International ed. in English) (2019)
Peptide-stabilized platinum nanoparticles (PtNPs) were developed that have significantly greater toxicity against hepatic cancer cells (HepG2) than against other cancer cells and non-cancerous liver cells. The peptide H-Lys-Pro-Gly-dLys-NH2 was identified by a combinatorial screening and further optimized to enable the formation of water-soluble, monodisperse PtNPs with average diameters of 2.5 nm that are stable for years. In comparison to cisplatin, the peptide-coated PtNPs are not only more toxic against hepatic cancer cells but have a significantly higher tumor cell selectivity. Cell viability and uptake studies revealed that high cellular uptake and an oxidative environment are key for the selective cytotoxicity of the peptide-coated PtNPs.
Keyphrases
  • induced apoptosis
  • water soluble
  • cell cycle arrest
  • oxidative stress
  • signaling pathway
  • endoplasmic reticulum stress
  • cell death
  • anti inflammatory
  • ionic liquid
  • pi k akt