Advanced age in humans and mouse models of glioblastoma show decreased survival from extratumoral influence.

Margaret O Johnson April Bell Kristen L Lauing Erik Ladomersky Lijie Zhai Manon Penco-Campillo Yajas Shah Elizabeth Mauer Joanne Xiu Theodore Nicolaides Michael R Drumm Kathleen McCortney Olivier Elemento Miri Kim Prashant V Bommi Justin T Low Ruba Memon Jennifer D Wu Junfei Zhao Xinlei Mi Michael J Glantz Soma Sengupta Brandyn Castro Bakhtiar Yamini Craig M Horbinski Darren J Baker Theresa L Walunas Gary E Schiltz Rimas V Lukas Derek A Wainwright

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

This work suggests a potential benefit for combining senolytics with immunotherapy in older patients with GBM.

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