A subtype of schizophrenia patients with altered methylation level of genes related to immune cell activity.

Chunyan LuoXuenan PiQi ZhangNa HuYuan XiaoJohn A SweeneyJeffrey R BishopQiyong GongDan XieSu Lui

Published in: Psychological medicine (2024)

In summary, this study demonstrated a subtype of schizophrenia patients across both FES and LTS cohorts, defined by widespread alterations in methylation profile of genes related to immune function and distinguishing clinical features. This finding illustrates the promise of novel treatment strategies targeting immune dysregulation for a subpopulation of schizophrenia patients.

Keyphrases

end stage renal disease
bipolar disorder
genome wide
newly diagnosed
chronic kidney disease
dna methylation
gene expression
machine learning
patient reported outcomes
big data
artificial intelligence