Liquid biopsies with circulating plasma HPV-DNA measurements - a clinically applicable surveillance tool for HPV-positive oropharyngeal cancer patients.

Kathrine Kronberg Jakobsen Simone Kloch Bendtsen Niels Pallisgaard Jeppe Friborg Giedrius Lelkaitis Christian Grønhøj Larsen Christian von Buchwald

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our study, comprising the largest study of HPV+/p16+ OPSCC patients, using an ultrasensitive multiplex HPV gene panel, revealed a high sensitivity of cfHPV-DNA detection in the liquid biopsies. We recommend serial plasma HPV samples for clinical monitoring of HPV+/p16+ OPSCC patients.

Keyphrases

high grade
end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
public health
gene expression
single molecule
ionic liquid
patient reported outcomes
cell free
genome wide
high resolution
single cell
label free
nucleic acid
patient reported
sensitive detection