Effector and Regulatory T Cell Trafficking in Corneal Allograft Rejection.
Afsaneh AmouzegarSunil K ChauhanPublished in: Mediators of inflammation (2017)
Corneal transplantation is among the most prevalent and successful forms of solid tissue transplantation in humans. Failure of corneal allograft is mainly due to immune-mediated destruction of the graft, a complex and highly coordinated process that involves elaborate interactions between cells of innate and adaptive immunity. The migration of immune cells to regional lymphoid tissues and to the site of graft plays a central role in the immunopathogenesis of graft rejection. Intricate interactions between adhesion molecules and their counter receptors on immune cells in conjunction with tissue-specific chemokines guide the trafficking of these cells to the draining lymph nodes and ultimately to the site of graft. In this review, we discuss the cascade of chemokines and adhesion molecules that mediate the trafficking of effector and regulatory T cells during corneal allograft rejection.
Keyphrases
- regulatory t cells
- induced apoptosis
- dendritic cells
- optical coherence tomography
- lymph node
- wound healing
- cell cycle arrest
- immune response
- kidney transplantation
- gene expression
- cataract surgery
- endoplasmic reticulum stress
- cell therapy
- transcription factor
- cystic fibrosis
- biofilm formation
- cell death
- mesenchymal stem cells
- sentinel lymph node
- rectal cancer