Decreased interferon-γ production by NK cells from KIR haplotype B carriers in hepatitis C virus infection.
Dalila MeleAnnamaria PasiRosalia CacciatoreStefania MantovaniBarbara OlivieroMario U MondelliStefania VarchettaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
Our data show that NK cells from HCV+ patients have an unbalanced ability to produce IFNγ and to kill target cells in haplotype A and B carriers, suggesting the existence of complex functional differences governed by KIR-HLA interaction, particularly on KIR3DL1 expressing NK cells.
Keyphrases
- nk cells
- hepatitis c virus infection
- end stage renal disease
- induced apoptosis
- ejection fraction
- newly diagnosed
- dendritic cells
- chronic kidney disease
- peritoneal dialysis
- immune response
- prognostic factors
- cell cycle arrest
- machine learning
- electronic health record
- signaling pathway
- endoplasmic reticulum stress
- big data
- cell proliferation
- cell death
- patient reported
- artificial intelligence
- pi k akt