Ru(II)/Ru(IV)-catalyzed C(sp 2 )-H allylation with alkene difunctionalization to access isochroman-1-imines.

Ashish JoshiShruti MoorthyLilesh Rambhai ChavadaSaurabh Kumar Singh Ashok Kumar Pandey

Published in: Chemical communications (Cambridge, England) (2023)

Merging C(sp 2 )-H allylation and alkene difunctionalization events to access isochroman-1-imines, using N -aroyl aminoesters, MBH acetates, and NBS, under Ru(II)/Ru(IV) catalysis has been developed. Using 1 H NMR, ESI-MS, HRMS, control reactions, deuterium labeling experiments, and DFT analysis, the allyl transfer (redox) process was proven to involve in C-H allylation rather than olefin insertion. Scale-up and synthetic transformations demonstrated the sustainability of this method.

Keyphrases

energy transfer
ms ms
mass spectrometry
multiple sclerosis
high resolution
high resolution mass spectrometry
quantum dots
solid state
simultaneous determination
ionic liquid